EXAMINE THIS REPORT ON PKRRATING

The activated enzyme then phosphorylates its main substrate, the translational initiation aspect eIF2α. The resulting translational arrest blocks viral replication. PKR belongs to the conserved household of 4 protein kinases (PKR, PERK, GCN2, HRI) that every one phosphorylate eIF2α in reaction to unique stimuli12, triggering the integrated anxiet